Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass.


Protein kinase B (PKB)/Akt is considered to be a key target downstream of insulin receptor substrate 2 (IRS2) in the regulation of beta-cell mass. However, while deficiency of IRS2 in mice results in diabetes with insulin resistance and severe failure of beta-cell mass and function, only loss of the PKBbeta isoform leads to a mild metabolic phenotype with… (More)
DOI: 10.1128/MCB.00719-09


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