Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity.

@article{Sun2005DifferentialEO,
  title={Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity.},
  author={Kai Sun and Danice E.C. Wilkins and Miriam Anver and Thomas Joseph Sayers and Angela Panoskaltsis-Mortari and Bruce R Blazar and Lisbeth A. Welniak and William Joseph Murphy},
  journal={Blood},
  year={2005},
  volume={106 9},
  pages={3293-9}
}
We have recently demonstrated that the proteasome inhibitor, bortezomib, administered immediately following murine allogeneic bone marrow transplantation (BMT) resulted in marked inhibition of acute graft-versus-host disease (GVHD) with retention of graft-versus-tumor effects. We now assessed the effects of delayed bortezomib administration (5 or more days after BMT) on GVHD. Recipient C57BL/6 (H2b) mice were lethally irradiated and given transplants of bone marrow cells and splenocytes from… CONTINUE READING
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