Differential effects of prolonged hyperglycemia on in vivo and in vitro insulin secretion in rats.

@article{Laury1991DifferentialEO,
  title={Differential effects of prolonged hyperglycemia on in vivo and in vitro insulin secretion in rats.},
  author={M. C. Laury and Fukuyama Takao and Dani{\`e}le Bailb{\'e} and Luc P{\'e}nicaud and Bernard Portha and Luc Picon and Alain Ktorza},
  journal={Endocrinology},
  year={1991},
  volume={128 5},
  pages={
          2526-33
        }
}
The purpose of this study was to investigate the effects of a 48-h glucose (30% wt/vol) infusion in unrestrained catheterized healthy rats (HG) on subsequent in vivo and in vitro insulin response to glucose. High hyperglycemia (400-450 mg/dl) and resulting hyperinsulinemia (1.2 +/- 0.1 mU/ml vs. 0.15 +/- 0.03 mU/ml in controls) were maintained throughout the infusion period. Glucose-induced insulin secretion was examined in vivo 3 h after the end of infusion by performing either a glucose… CONTINUE READING

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