Differential effects of polychlorinated biphenyl congeners on serum thyroid hormone levels in rats.

@article{Martin2010DifferentialEO,
  title={Differential effects of polychlorinated biphenyl congeners on serum thyroid hormone levels in rats.},
  author={Lori Martin and Curtis D. Klaassen},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2010},
  volume={117 1},
  pages={36-44}
}
Polychlorinated biphenyls (PCBs) are known to reduce serum thyroxine (T(4)) in rats, but the relative effects of individual PCB congeners on thyroid hormones are not known. Thus, male Sprague-Dawley rats were administered Aroclor 1254, Aroclor 1242 (4, 8, 16, or 32 mg/kg/day), PCB 95 (2,2',3,5',6-pentachlorobiphenyl), PCB 99 (2,2',4,4',5-pentachlorobiphenyl), PCB 118 (2,3',4,4',5-pentachlorobiphenyl) (2, 4, 8, or 16 mg/kg/day), PCB 126 (3,3'4,4',5-pentachlorobiphenyl) (2.5, 5, 10, 20, or 40… CONTINUE READING

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References

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Showing 1-10 of 44 references

Comprehensive, quantitative, congener specific analyses of eight aroclors and complete PCB congener assignments on DB-1 capillary GC columns

  • G. M. Frame, R. M. Wagner, +5 authors D. L. Bedard
  • Chemosphere 33, 603–623.
  • 1996
Highly Influential
8 Excerpts

Consideration of enzyme and endocrine interactions in the risk assessment of PCBs

  • M. H. Li, L. G. Hansen
  • Rev. Toxicol. 1, 71–156.
  • 1997
Highly Influential
8 Excerpts

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