Differential effects of phorbol myristate acetate and dexamethasone on protein kinase C activity and eicosanoids production in cultured rat astrocytes.

@article{Boneh1993DifferentialEO,
  title={Differential effects of phorbol myristate acetate and dexamethasone on protein kinase C activity and eicosanoids production in cultured rat astrocytes.},
  author={A. Boneh and Esther Shohami and Talma Brenner},
  journal={Journal of neuroscience research},
  year={1993},
  volume={34 6},
  pages={
          629-34
        }
}
The effects of phorbol myristate acetate (PMA) and dexamethasone on protein kinase C (PK-C) activity and eicosanoid production were characterized in primary cultures of rat glial cells. PMA (1,000 ng/ml) treatment for 2 hr resulted in a maximal effect (a 4-fold increase in PGE2 production). Longer exposure to PMA (up to 96 hr) resulted in attenuation of PGE2 production. Down-regulation of PK-C activity was assessed in glial cell homogenates under these conditions. Although a 70% inhibition of… CONTINUE READING
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