Differential effects of peptide histidine isoleucine (PHI) and related peptides on stimulation and suppression of neuroblastoma cell proliferation. A novel VIP-independent action of PHI via MAP kinase.

@article{Lelievre1998DifferentialEO,
  title={Differential effects of peptide histidine isoleucine (PHI) and related peptides on stimulation and suppression of neuroblastoma cell proliferation. A novel VIP-independent action of PHI via MAP kinase.},
  author={Vincent Lelievre and Nicolas Pineau and Jie Du and Chua Hui Wen and Thao Tran Nhu Nguyen and Thierry Janet and J. M. Muller and James A. Waschek},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 31},
  pages={19685-90}
}
The growth rate of rodent embryonic neuroblasts and human neuroblastoma cell lines is regulated in part by autocrine or paracrine actions of neuropeptides of the family that includes vasoactive intestinal peptide (VIP), peptide histidine isoleucine (PHI), and pituitary adenylate cyclase-activating peptide (PACAP). These peptides act via seven transmembrane G-protein-linked receptors coupled to cAMP elevation, phospholipase C activation, intracellular Ca2+ release, and/or of mitogen-activated… CONTINUE READING