Differential effects of parathyroid hormone and somatomedin-like growth factors on the sizes of proteoglycan monomers and their synthesis in rabbit costal chondrocytes in culture.

@article{Hiraki1985DifferentialEO,
  title={Differential effects of parathyroid hormone and somatomedin-like growth factors on the sizes of proteoglycan monomers and their synthesis in rabbit costal chondrocytes in culture.},
  author={Yuji Hiraki and Yasutaka Yutani and Masaharu Takigawa and Yukio Kato and Fujio Suzuki},
  journal={Biochimica et biophysica acta},
  year={1985},
  volume={845 3},
  pages={445-53}
}
In the proteoglycans extracted from rabbit costal chondrocytes in culture, two populations of proteoglycans were distinguished by density gradient centrifugation under dissociative conditions. The major component was the faster sedimenting population (proteoglycan I), the putative 'cartilage-specific' proteoglycans, and the minor component was the slower sedimenting population (proteoglycan II). The monomeric size of proteoglycan I was closely related to the differentiation-state of… CONTINUE READING