Differential effects of parainfluenza virus type 3 on human monocytes and dendritic cells.

@article{PlotnickyGilquin2001DifferentialEO,
  title={Differential effects of parainfluenza virus type 3 on human monocytes and dendritic cells.},
  author={H{\'e}l{\`e}ne Plotnicky-Gilquin and D Cyblat and J. P. Aubry and Yves Delneste and Aline Blaecke and Jean Yves Bonnefoy and Nathalie Corva{\"i}a and Pascale Jeannin},
  journal={Virology},
  year={2001},
  volume={285 1},
  pages={82-90}
}
To understand the lack of protective immunity observed after infection with parainfluenza virus type 3 (PIV3), we tested the effect of the virus on human monocytes and monocyte-derived immature dendritic cells (DCs). Expression of viral antigens on the cell surfaces correlated with replication of the virus, which was marginal in monocytes but extremely efficient in DCs. The virus increased monocyte survival at least in part through the production of granulocyte-macrophage colony-stimulating… CONTINUE READING

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