Differential effects of oxazepam and lorazepam on aggressive responding

  title={Differential effects of oxazepam and lorazepam on aggressive responding},
  author={Alyson J. Bond and Malcolm Harold Lader},
Two doses of two very similar benzodiazepines (oxazepam 15 and 30 mg: lorazepam 1 and 2 mg) and placebo were compared 4 h post-administration on a competitive reaction time task designed to measure behavioural aggression. Forty-five subjects were assigned randomly to five independent drug groups. Subjective ratings of mood, anxiety and aggression were completed pre- and post-drug and post-task. Oxazepam and lorazepam had very similar subjective effects, but the higher dose of lorazepam… 

Acute effects of lorazepam on laboratory measures of aggressive and escape responses of adult male parolees

It is suggested that while lorazepam often produces sedation, it also modifies human aggressive responding, in part, by suppressing reactions to aversive stimuli.

Differential effects of six structurally related benzodiazepines on some ethological measures of timidity, aggression and locomotion in mice

The present study suggests that 2′ deschloro-phenyl-benzodiazepines are less “sedative” with respect to their “anxiolytic” activity.

Individual differences in aggressive responding to intravenous flumazenil administration in adult male parolees

Investigation of the effects of acute administrations of flumazenil on aggressive responding in adult humans found that aggressive responses varied across subjects, and additional laboratory research is needed to better clarify the behavioural mechanisms by which BZD receptor antagonists modify human aggressive responding.

Benzodiazepines and heightened aggressive behavior in rats: reduction by GABAA/α1 receptor antagonists

The carboline derivatives, β-CCt and 3-PBC, antagonists with preferential action at the GABAA receptors with α1 subunits, may antagonize benzodiazepine-heightened aggression, thus implicating the α1Subunit in heightened aggression.

The effect of tryptophan depletion and enhancement on subjective and behavioural aggression in normal male subjects

It is concluded that, in those with pre-existing aggressive traits, acute falls in central 5-HT can cause increased subjective and objective aggression, while rises can have the opposite effect.

Effects of acute tiagabine administration on aggressive responses of adult male parolees

A possible behavioral mechanism for the rate-decreasing effects on aggressive responding produced in the present study is that tiagabine may modify aggressive responding by suppressing reactions to aversive stimuli.

Psychiatry and the Law Part III: The Psychopharmacology of Long-Term Aggression—Toward an Evidence-Based Algorithm

A review of the literature demonstrates that evidence exists for the use of these agents in various syndromes presenting with aggressive behaviour, including serotonin reuptake inhibitors (SRIs), trazodone, buspirone and the benzodiazepines.

GABAA/α1 receptor agonists and antagonists: effects on species-typical and heightened aggressive behavior after alcohol self-administration in mice

Benzodiazepine antagonists, particularly those acting preferentially at GABAA/α1 subunit-containing receptors, decrease alcohol-heightened and species-typical aggressive behavior, but are ineffective in attenuating the sedative effects of alcohol.



Differential amnesic properties of benzodiazepines: a dose-response comparison of two drugs with similar elimination half-lives

It is concluded that drugs with similar half-lives may have similar effects on some cognitive and mood factors but be completely different in terms of amnesic effects, andDiffering potencies of the two drugs may be a more important factor determining amnesia side-effects.

Impaired performance and sedation after a single dose of lorazepam

In a double-blind cross-over study using normal student volunteers, the effects of 1 and 2.5 mg lorazepam on self-rated mood and bodily symptoms, as well as performance in a number of tests were

The differential effects of chlordiazepoxide and oxazepam on hostility in a small group setting.

The authors compared the effects of chlordiazepoxide, oxazepam, and placebo on hostility, as an inner motivational or arousal state, in moderately and highly anxious male research volunteers. The

Differential actions of chlordiazepoxide and oxazepam on hostility.

The present study was designed to examine specifically whether this differential effect of chlordiazepoxide and oxazepam acted differentially in altering hostile and aggressive feelings in a population of student volunteers.

The relationship between induced behavioural aggression and mood after the consumption of two doses of alcohol.

It was found that subjects on alcohol responded more aggressively but rated themselves as less angry compared to subjects on placebo, and alcohol had positive dose-related mood effects.

Effects of diazepam (Valium) and trait anxiety on human physical aggression and emotional state

Trait anxiety appears to mediate the effects of diazepam on both mood states and aggressive behavior, and is consistent with reports of the ability of antianxiety drugs to disinhibit suppressed behaviors.


Benzodiazepines and their antagonists: A pharmacoethological analysis with particular reference to effects on “aggression”

The effects of personality type on drug response.

  • R. McDonald
  • Psychology, Biology
    Archives of general psychiatry
  • 1967
The most marked paradoxical responses have been reported in relation to phenothiazine usage where, not infrequently, patients become markedly more agitated and anxious, rather than calmer and less anxious as would be expected from the pharmacological properties of Phenothiazines.

Benzodiazepines: a summary of pharmacokinetic properties.

Drugs in this category have long-acting pharmacologically active metabolites, accumulate extensively during multiple dosage, and may have impaired clearance in the elderly and those with liver disease.