Differential effects of ovarian steroids on anxiety versus fear as measured by open field test and fear-potentiated startle.

@article{Hiroi2006DifferentialEO,
  title={Differential effects of ovarian steroids on anxiety versus fear as measured by open field test and fear-potentiated startle.},
  author={Ryoko Hiroi and John F. Neumaier},
  journal={Behavioural brain research},
  year={2006},
  volume={166 1},
  pages={93-100}
}
The ovarian steroids, estrogen (E) and progesterone (P), have been shown to affect anxiety and fear in humans and animals, although with inconsistent results. These ambiguous findings may be due to differential actions of ovarian steroids on anxiety versus fear. To investigate such a role, we used the open field test (OFT) and fear-potentiated startle (FPS). We examined these behaviors between cycling female rats in proestrus (high E and rising P) or diestrus (low E and P), as well as between… CONTINUE READING