Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women.

@article{Vongpatanasin2003DifferentialEO,
  title={Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women.},
  author={Wanpen Vongpatanasin and Meryem Tuncel and Zhongyun Wang and Debbie Arbique and Borna Mehrad and Ishwarlal Jialal},
  journal={Journal of the American College of Cardiology},
  year={2003},
  volume={41 8},
  pages={1358-63}
}
OBJECTIVES We investigated whether the route of estrogen replacement therapy (ET) is the major determinant of C-reactive protein (CRP) in postmenopausal women. BACKGROUND Recent studies demonstrated that oral ET causes a sustained increase in CRP, implicating a proinflammatory effect. Because CRP is synthesized in the liver, we hypothesized that estrogen-induced CRP elevation is related to first-pass hepatic metabolism. METHODS In 21 postmenopausal women, we conducted a randomized… CONTINUE READING