Differential effects of omega-3 fish oils on protein kinase activities in vitro.

@article{Speizer1991DifferentialEO,
  title={Differential effects of omega-3 fish oils on protein kinase activities in vitro.},
  author={L A Speizer and Melissa J Watson and Laurence L. Brunton},
  journal={The American journal of physiology},
  year={1991},
  volume={261 1 Pt 1},
  pages={E109-14}
}
We studied the in vitro effects of omega-3 fish oils and other fatty acids on the activity of crude protein kinase C from S49 lymphoma cells, on partially purified enzyme from rat cerebrum, on homogeneous protein kinase C from bovine brain, and, for comparison, on type I adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase. In the absence of exogenous phospholipid, the fish oils cis-5,8,11,14,17-eicosapentaenoic acid (EPA) and acid (DCHA) enhance the catalytic cis-4,7,10,13,16… CONTINUE READING

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