Differential effects of neonatal endotoxemia on heart and kidney carnitine palmitoyl transferase I.

@article{Fukumoto2002DifferentialEO,
  title={Differential effects of neonatal endotoxemia on heart and kidney carnitine palmitoyl transferase I.},
  author={Koji Fukumoto and Agostino Pierro and L. Spitz and Simon Eaton},
  journal={Journal of pediatric surgery},
  year={2002},
  volume={37 5},
  pages={723-6}
}
BACKGROUND/PURPOSE The heart and kidney are both affected in sepsis-related multiple organ failure. Both utilize fatty acid substrates during the neonatal period, and impairment of oxidative metabolism during sepsis could lead to bioenergetic failure. The enzyme carnitine palmitoyl transferase I (CPT I) is important in the control of fat oxidation in the neonatal period. The aim of this study was to determine the effects of sepsis on neonatal cardiac and renal CPT I. METHODS Suckling rats… CONTINUE READING

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