Differential effects of naproxen and rofecoxib on the development of hypersensitivity following nerve injury in rats

@article{Padi2004DifferentialEO,
  title={Differential effects of naproxen and rofecoxib on the development of hypersensitivity following nerve injury in rats},
  author={Satyanarayana S. V. Padi and Shrinivas Krishnarao Kulkarni},
  journal={Pharmacology Biochemistry and Behavior},
  year={2004},
  volume={79},
  pages={349-358}
}
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GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury
Protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) on immobilization stress-induced behavioral and biochemical alterations in mice.
Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms.
[Analgesic effect of COX inhibitors and its mechanism in a rat model of neuropathic pain].
TLDR
Parecoxib can alleviate neuropathic hypersensitivity in rats, but this effect may not be associated with NR2B expression in the spinal cord.
A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4
EFFECT OF ACAMPROSATE IN EXPERIMENTAL MODELS OF PERIPHERAL NEUROPATHIC AND INFLAMMATORY PAIN IN WISTAR RATS
TLDR
Single dose treatment with acamprosate did not produce significant anti-inflammatory and anti-hyperalgesic effects, in carrageenan-induced inflammatory pain model and, repeated administration of acampsrosate ameliorates the behavioural symptoms of neuropathic pain observed.
Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats.
Intracisternal administration of COX inhibitors attenuates mechanical allodynia following compression of the trigeminal ganglion in rats
Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats.
Electroacupuncture versus celecoxib for neuropathic pain in rat SNL model
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References

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Hyperalgesia due to nerve injury: role of prostaglandins
Cyclooxygenase‐2 inhibition by rofecoxib reverses naturally occurring fever in humans
Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain
Induction, blockade and restoration of a persistent hypersensitive state
Cyclooxygenase-1 in the Spinal Cord Is Altered after Peripheral Nerve Injury
TLDR
The data suggest that COX-1 expression in the spinal cord is not static, but changes in a time- and laminar-dependent manner after nerve injury, consistent with observations by others that spinally administered specific COx-1 inhibitors may be useful to prevent and treat neuropathic pain.
Peri-sciatic administration of indomethacin early after nerve injury can attenuate the development of tactile allodynia in a rat model of L5 single spinal nerve injury
Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat
TLDR
M and K produced hypoalgesia after intrathecal administration in rats with CCI, with M being more potent than K at an equimolar dose range and the analgesic effect of K was equal toequimolar doses of M for alleviation of cold allodynia.
Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain
TLDR
The data suggest that PSNL induces over‐production of PGs in peripheral tissues and that PGs probably sensitize nociceptors and are involved in central plasticity and sensitization at the spinal cord level, thus contributing to the maintenance of tactile allodynia.
Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance p, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation
Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury
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