Differential effects of naproxen and rofecoxib on the development of hypersensitivity following nerve injury in rats

@article{Padi2004DifferentialEO,
  title={Differential effects of naproxen and rofecoxib on the development of hypersensitivity following nerve injury in rats},
  author={Satyanarayana S. V. Padi and Shrinivas Krishnarao Kulkarni},
  journal={Pharmacology Biochemistry and Behavior},
  year={2004},
  volume={79},
  pages={349-358}
}
[Analgesic effect of COX inhibitors and its mechanism in a rat model of neuropathic pain].
TLDR
Parecoxib can alleviate neuropathic hypersensitivity in rats, but this effect may not be associated with NR2B expression in the spinal cord.
EFFECT OF ACAMPROSATE IN EXPERIMENTAL MODELS OF PERIPHERAL NEUROPATHIC AND INFLAMMATORY PAIN IN WISTAR RATS
TLDR
Single dose treatment with acamprosate did not produce significant anti-inflammatory and anti-hyperalgesic effects, in carrageenan-induced inflammatory pain model and, repeated administration of acampsrosate ameliorates the behavioural symptoms of neuropathic pain observed.
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TLDR
The data suggest that COX-1 expression in the spinal cord is not static, but changes in a time- and laminar-dependent manner after nerve injury, consistent with observations by others that spinally administered specific COx-1 inhibitors may be useful to prevent and treat neuropathic pain.
Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat
TLDR
M and K produced hypoalgesia after intrathecal administration in rats with CCI, with M being more potent than K at an equimolar dose range and the analgesic effect of K was equal toequimolar doses of M for alleviation of cold allodynia.
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The data suggest that PSNL induces over‐production of PGs in peripheral tissues and that PGs probably sensitize nociceptors and are involved in central plasticity and sensitization at the spinal cord level, thus contributing to the maintenance of tactile allodynia.
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