Differential effects of molecular chaperones on refolding of homologous proteins.

Abstract

Three homologous aspartate aminotransferases with virtually identical spatial structures and pairwise amino acid sequence identities of > 40% differ markedly with respect to the yield of renaturation upon dilution from 6 M guanidine hydrochloride (mitochondrial << cytosolic < Escherichia coli). The enzymes also respond differently to molecular chaperones… (More)

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