Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice.

@article{Gurkan2003DifferentialEO,
  title={Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice.},
  author={Ozlem U Gurkan and Christopher O'donnell and Roy Brower and Emily Ruckdeschel and Patrice M. Becker},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2003},
  volume={285 3},
  pages={L710-8}
}
Patients with acute respiratory distress syndrome are at increased risk for developing multiorgan system dysfunction. The goal of this study was to establish an in vivo murine model to assess the differential effects of ventilation-protective strategies on the development of acute lung injury and systemic organ inflammation. C57B/6 mice were randomized to mechanical ventilation (MV) with conventional, high (17 ml/kg) or protective, low (6 ml/kg) tidal volume (VT) after intratracheal… CONTINUE READING