Differential effects of maternal betamethasone and cortisol on lung maturation and growth in fetal sheep.

@article{Jobe2003DifferentialEO,
  title={Differential effects of maternal betamethasone and cortisol on lung maturation and growth in fetal sheep.},
  author={Alan Hall Jobe and John P. Newnham and Timothy J. M. Moss and Machiko Ikegami},
  journal={American journal of obstetrics and gynecology},
  year={2003},
  volume={188 1},
  pages={22-8}
}
OBJECTIVES We asked whether maternal or fetal cortisol treatments induced fetal lung maturation and growth restriction compared with betamethasone and whether medroxyprogesterone (MPA) influenced lung maturation. STUDY DESIGN Pregnant sheep were randomized to receive MPA or saline solution at 100 days of gestation. At 117 days of pregnancy, ewes were randomized to receive maternal or fetal treatments with 0.5 mg/kg betamethasone, four injections of hydrocortisone given over 4.5 hours or… CONTINUE READING