Differential effects of macrophage inflammatory chemokine-2 and keratinocyte-derived chemokine on hemorrhage-induced neutrophil priming for lung inflammation: assessment by adoptive cells transfer in mice.

@article{Lomas2003DifferentialEO,
  title={Differential effects of macrophage inflammatory chemokine-2 and keratinocyte-derived chemokine on hemorrhage-induced neutrophil priming for lung inflammation: assessment by adoptive cells transfer in mice.},
  author={Joanne L Lomas and Chun-Shiang Chung and Patricia S. Grutkoski and Brian W. Leblanc and Liz M. Lavigne and Jonathan S Reichner and Stephen H. Gregory and Lesley A. Doughty and William G. Cioffi and Alfred Ayala},
  journal={Shock},
  year={2003},
  volume={19 4},
  pages={358-65}
}
Prior studies have shown that hemorrhage (Hem) can serve as a priming stimulus for acute lung injury (ALI) triggered by subsequent septic challenge (cecal ligation and puncture, CLP). Furthermore, we have reported that in vivo antibody neutralization of the chemokines, macrophage inflammatory chemokine-2 (MIP-2) and keratinocyte-derived chemokine (KC), immediately after Hem appears to differentially effect the onset of ALI. However, although we hypothesize that this is due to divergent effects… CONTINUE READING
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