Differential effects of low-dose decitabine on immune effector and suppressor responses in melanoma-bearing mice

@article{Triozzi2012DifferentialEO,
  title={Differential effects of low-dose decitabine on immune effector and suppressor responses in melanoma-bearing mice},
  author={Pierre L Triozzi and Wayne Aldrich and Susan Achberger and Selvarangan Ponnazhagan and Oscar Alcazar and Yogen Saunthararajah},
  journal={Cancer Immunology, Immunotherapy},
  year={2012},
  volume={61},
  pages={1441-1450}
}
Low doses of the demethylating agent decitabine have been shown to enhance the sensitivity of tumors to immune effector cells and molecules through upregulation of tumor antigen presentation and apoptotic pathways. Effects on host immune effector and suppressor responses have not been well characterized. Mice bearing B16 melanoma were treated with low-dose decitabine, cytokine, interleukin-2 (IL-2), toll-like receptor 9 agonist ODN1826, and/or a viral vectored vaccine targeting the melanoma… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Epigenetic regulation of melanoma diVerentiation in vitro and in vivo

O Alcazar, S Achberger, +4 authors PL Triozzi
2011
View 7 Excerpts
Highly Influenced

potency

LI Sánchez-Abarca, S Gutierrez-Cosio, +12 authors JA Pérez-Simon
2010

Similar Papers

Loading similar papers…