Differential effects of low- and high-dose estrogen treatments on vascular responses in female rats.

@article{Bolego1997DifferentialEO,
  title={Differential effects of low- and high-dose estrogen treatments on vascular responses in female rats.},
  author={Chara Bolego and Andrea Cignarella and R. Ruzza and Christian Zaarour and Elio Messi and Mariarosa Zanisi and Lina Puglisi},
  journal={Life sciences},
  year={1997},
  volume={60 25},
  pages={
          2291-302
        }
}
In an attempt to study the mechanisms by which estrogens affect vascular responses, we utilized aortic preparations from intact and ovariectomized female rats receiving low- and high-dose subcutaneous estrogen treatments. Oil-treated, as well as male rats, served as controls. In ovariectomized females, low-dose 17-beta-estradiol injections (5 microg/kg daily for two days) affected the basal release of nitric oxide, as evaluated by concentration-related curves to superoxide dismutase and N(G… CONTINUE READING
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