Differential effects of low and high concentrations of 4-aminopyridine on axonal conduction in normal and injured spinal cord.

Blockade of potassium channels with the drug 4-aminopyridine has been shown to effect recovery of action potential conduction in myelinated axons under a variety of pathological conditions, but the mechanism and significance of this phenomenon are not completely understood. This study examined the effects of a range of 4-aminopyridine concentrations on… CONTINUE READING