Differential effects of leucine and methionine enkephalin on morphine-induced analgesia, acute tolerance and dependence.

@article{Vaught1979DifferentialEO,
  title={Differential effects of leucine and methionine enkephalin on morphine-induced analgesia, acute tolerance and dependence.},
  author={Jeffry L. Vaught and Akihiro Takemori},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1979},
  volume={208 1},
  pages={86-90}
}
Intracerebroventricular (40-80 microgram) or i.p. (5-20 mg/kg) injection of leucine enkephalin 15 min before or after s.c. morphine administration resulted in a marked, dose-dependent enhancement of morphine analgesia as measured by the mouse tail-flick assay. Further, i.p. injection of leucine enkephalin (5 mg/kg) enhanced the analgesia produced by methadone and levorphanol in the tail-flick assay but not that by nalorphine in the abdominal constriction assay. Met- but not leu-enkephalin was… CONTINUE READING
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