Differential effects of intravenous anesthetics on capacitative calcium entry in human pulmonary artery smooth muscle cells.

  title={Differential effects of intravenous anesthetics on capacitative calcium entry in human pulmonary artery smooth muscle cells.},
  author={Mikyung Yang and Xueqin Ding and Paul A. Murray},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={294 5},
We assessed the roles of the protein kinase C (PKC) and the tyrosine kinase (TK) signaling pathways in regulating capacitative calcium entry (CCE) in human pulmonary artery smooth muscle cells (PASMCs) and investigated the effects of intravenous anesthetics (midazolam, propofol, thiopental, ketamine, etomidate, morphine, and fentanyl) on CCE in human PASMCs. Fura-2-loaded human PASMCs were placed in a dish (37 degrees C) on an inverted fluorescence microscope. Intracellular Ca2+ concentration… 

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