Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells

@article{Leclercq1996DifferentialEO,
  title={Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells},
  author={Georges Leclercq and Veronique Debacker and Magda de Smedt and Jean Plum},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={184},
  pages={325 - 336}
}
Bipotential T/natural killer (NK) progenitor cells are destined to differentiate mainly into T cell receptor (TCR) alpha beta and TCR gamma delta cells in a thymic microenvironment, whereas extrathymically they selectively develop into NK cells. The exact environmental conditions that are required for differentiation into these three leukocyte populations are largely unknown. In this report, we have investigated and compared the effect of interleukin (IL)-15 and IL-2 in this process. The IL-15… CONTINUE READING

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