Differential effects of in vivo ethanol on LPS-induced TNF and nitric oxide production in the lung.

@article{Kolls1995DifferentialEO,
  title={Differential effects of in vivo ethanol on LPS-induced TNF and nitric oxide production in the lung.},
  author={Jay K Kolls and Jianming Xie and Dinghua Lei and Stan S. Greenberg and W. Summer and Steve Nelson},
  journal={The American journal of physiology},
  year={1995},
  volume={268 6 Pt 1},
  pages={
          L991-8
        }
}
Alcohol (EtOH) has been shown to suppress lipopolysaccharide (LPS)-induced nitric oxide (NO) generation and tumor necrosis factor (TNF) production in the lung in vivo. We have previously reported that EtOH suppressed gene expression for inducible nitric oxide synthase (iNOS) with a subsequent decrease in release of reactive nitrogen intermediates by alveolar macrophages and recruited lung neutrophils. We hypothesized that a similar mechanism may be involved in EtOH-induced suppression of LPS… CONTINUE READING
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