Differential effects of imipramine in rats as a function of DRL schedule value.

@article{McGuire1980DifferentialEO,
  title={Differential effects of imipramine in rats as a function of DRL schedule value.},
  author={Patricia S. McGuire and Lewis S. Seiden},
  journal={Pharmacology, biochemistry, and behavior},
  year={1980},
  volume={13 5},
  pages={691-4}
}
Imipramine, a tricyclic anti-depressant, has selective effects on differential-reinforcement-of-low-response-rate (DRL) schedule performance as a function of schedule value. On a DRL 9-sec schedule of water reinforcement, imipramine at doses of 2.5 to 20.0 mg/kg resulted in no significant change in the number of reinforcements or responses. A dose of 5.0 mg/kg imipramine, given to rats performing on a DRL > 72-sec schedule, produced a significant increase in the number of reinforcements and a… CONTINUE READING

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