Differential effects of human natural interferon-alpha and mismatched double-stranded RNA against a human renal cell carcinoma xenograft.

@article{Hubbell1990DifferentialEO,
  title={Differential effects of human natural interferon-alpha and mismatched double-stranded RNA against a human renal cell carcinoma xenograft.},
  author={Howard R. Hubbell and Edward C. Pequignot and K R Shanabrook and W. A. Carter and Richard D. Williams and David R. Strayer},
  journal={Anticancer research},
  year={1990},
  volume={10 3},
  pages={795-801}
}
The antitumor effects of natural human IFN-alpha and mismatched dsRNA against the human renal cell carcinoma cell line 786-0 were studied both in a clonogenic soft agar assay and in the nude mouse. The 786-0 cells were sensitive in vitro to the antiproliferative effects of IFN-alpha in a dose-response manner, up to 3000 IRU/ml. These cells were also sensitive, in a dose-dependent manner, to mismatched dsRNA in the clonogenic assay. Mismatched dsRNA was effective in inhibiting tumor growth (p… CONTINUE READING