Differential effects of human immunodeficiency virus type 1 Vpu on the stability of BST-2/tetherin.


BST-2/CD317/tetherin is a host factor that inhibits the release of HIV-1 and other unrelated viruses. A current model proposes that BST-2 physically tethers virions to the surface of virus-producing cells. The HIV-1-encoded Vpu protein effectively antagonizes the activity of BST-2. How Vpu accomplishes this task remains unclear; however, it is known that… (More)
DOI: 10.1128/JVI.02080-10

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