Differential effects of heptanol, potassium, and tetrodotoxin on reentrant ventricular tachycardia around a fixed obstacle in anisotropic myocardium.

@article{Brugada1991DifferentialEO,
  title={Differential effects of heptanol, potassium, and tetrodotoxin on reentrant ventricular tachycardia around a fixed obstacle in anisotropic myocardium.},
  author={Josep Brugada and Llu{\'i}s Mont and Lucas V A Boersma and Charles J. H. J. Kirchhof and M. A. Allessie},
  journal={Circulation},
  year={1991},
  volume={84 3},
  pages={1307-18}
}
BACKGROUND The aim of this study was to test the hypothesis that electrical uncoupling and depression of the fast sodium channels have differential effects on propagation of the electrical impulse relative to the fiber orientation. METHODS AND RESULTS In a model of reentrant ventricular tachycardia (VT) (mean cycle length, 144 +/- 13 msec) around a ring… CONTINUE READING