Differential effects of growth hormone on cardiomyocyte and extracellular matrix protein remodeling following experimental myocardial infarction.

@article{Grimm1998DifferentialEO,
  title={Differential effects of growth hormone on cardiomyocyte and extracellular matrix protein remodeling following experimental myocardial infarction.},
  author={Daniela Grimm and Douglas F Cameron and Daniel P. Griese and G A Riegger and Eckhard P. Kromer},
  journal={Cardiovascular research},
  year={1998},
  volume={40 2},
  pages={297-306}
}
OBJECTIVES Growth hormone (GH) causes cardiomyocyte hypertrophy without development of fibrosis in the normal rat heart. The aim of this study was to evaluate the effects of GH on cardiac remodeling following experimental myocardial infarction (MI). METHODS Following ligation of the left coronary artery or sham operation, rats were randomized to receive 2 IU GH/kg/day or vehicle for four weeks (n = 140). Extracellular matrix proteins were assessed in the non-infarcted myocardium of the… CONTINUE READING

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