Differential effects of glycoprotein B epitope-specific antibodies on human cytomegalovirus-induced cell-cell fusion.

Abstract

Attachment of, and cell-cell fusion induced by, human cytomegalovirus were studied in the presence of neutralizing monospecific antibodies against antigenic domains 1 (AD-1) or 2 (AD-2) of glycoprotein B (gB, gpUL55). Efficient inhibition of the virion-mediated fusion event was consistently observed for the human AD-2-specific antibody as determined by a… (More)

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