Differential effects of glutamate agonists and d-aspartate on oxytocin release from hypothalamus and posterior pituitary of male rats

@article{Pampillo2001DifferentialEO,
  title={Differential effects of glutamate agonists and d-aspartate on oxytocin release from hypothalamus and posterior pituitary of male rats},
  author={Macarena Pampillo and Maria del Carmen Vera Diaz and Beatriz Hayd{\'e}e Duvilanski and Val{\'e}ria Rettori and Adriana Seilicovich and Mercedes Lasaga},
  journal={Endocrine},
  year={2001},
  volume={15},
  pages={309-315}
}
In order to determine whether ionotropic (iGluRs) and metabotropic (mGluRs) glutamate receptor activation modulates oxytocin release in male rats, we investigated the effect of agonists of both types of glutamate receptors on oxytocin release from hypothalamus and posterior pituitary. Kainate and quisqualate (1 mM) increased hypothalamic oxytocin release. Their effects were prevented by selective AMPA/kainate receptor antagonists. NMDA (0.01–1 mM) did not modify hypothalamic oxytocin release… CONTINUE READING
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