Differential effects of general amino acid control of lysine biosynthesis on penicillin formation in strains of Penicillium chrysogenum.

  title={Differential effects of general amino acid control of lysine biosynthesis on penicillin formation in strains of Penicillium chrysogenum.},
  author={C H{\"o}nlinger and W. Hampel and Max R{\"o}hr and Christian Peter Kubicek},
  journal={The Journal of antibiotics},
  volume={41 2},
The biosynthesis of penicillin by strains Penicillium chrysogenum requires a supply of of the amino acids valine, cysteine and a-aminoadipic acid1}. a-Aminoadipic acid has received most attention since it is an intermediate of lysine biosynthesis in fungi2) and therefore forms a branch point between lysine and penicillin biosynthesis in P. chrysogenumz~6). Higher producing strains of P. chrysogenum were shown to contain higher intracellular a-aminoadipate pool concentrations during penicillin… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 10 references

Kubicek : Lysine biosynthesis in Penicillium chrysogenum strains : Regulation by general amino acid control and absence of lysine repression

W. M. Jaklitsch, M. Rohr, P. C.

Gamerith : aAminoadipate pool concentration and penicillin biosynthesis in strains of Penicillium chrysogenum

W. M. Jaklitsch, W. Hampel, M. Rohr, C. P. Kubicek, G.
Can . J . Microbiol . • 1986

Martin : Glucose represses formation of 3( Laaminoadipyl )LcysteinylDvaline and isopenicillin N synthase but not penicillin acyltransferase in Penicillium chry257 sogenum

G. Revilla, F. R. Ramos, M. J. Lopez-Nieto, E. Alvarez, F. J.
J . Bacteriol . • 1986

Tarvin : Rapid analysis of amino acids using precolumn derivatization

J . Chromatogr . • 1984

Biosynthesis of / ?lactam antibiotics

N. A. Solomon

Positive regulation in the general amino acid control of Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America • 1983

Demain : Uptake and metabolism of aaminoadipate in Penicillium chrysogenum Wis 541255

C. G. Friedrich, L. A.
Arch . Microbiol . • 1978

Chattaway : Lysine control of aaminoadipate and penicillin synthesis in Penicillium chrysogenum

S. A. Goulden, W. F.
Biochem . J . • 1968

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