Differential effects of gallium nitrate on T lymphocyte and endothelial cell activation.

@article{Huang1994DifferentialEO,
  title={Differential effects of gallium nitrate on T lymphocyte and endothelial cell activation.},
  author={Emina Huang and D M Gabler and M E Krecic and Nicholas Gerber and Ronald M. Ferguson and Charles G. Orosz},
  journal={Transplantation},
  year={1994},
  volume={58 11},
  pages={1216-22}
}
The immunosuppressive agents used clinically to prevent allograft rejection exert their effects by interfering with antigen-dependent T cell activation, endothelial cell function, or both. Gallium nitrate (GN) is immunosuppressive both in vitro and in vivo, and has potential for clinical use in transplant recipients. Therefore, we analyzed the influence of GN on gonadal vein endothelial cell (GVEC) and T cell activation. GVEC were stimulated with IFN gamma or TNF alpha in the presence or… CONTINUE READING