Differential effects of fluoxetine and imipramine on the phosphorylation of the transcription factor CREB and cell-viability.

@article{Koch2003DifferentialEO,
  title={Differential effects of fluoxetine and imipramine on the phosphorylation of the transcription factor CREB and cell-viability.},
  author={Jakob M Koch and Susanne Kell and Josef Bernd Aldenhoff},
  journal={Journal of psychiatric research},
  year={2003},
  volume={37 1},
  pages={53-9}
}
It has been shown that antidepressants increase the expression of CREB (cAMP-response-element-binding-protein) and BDNF (brain derived neurotrophic factor) in vivo. Apparently inconsistent to these survival-promoting properties for many years antidepressants are known to induce apoptosis in various cell types in vitro. In the present study we evaluated if the antidepressants imipramine and fluoxetine are capable to influence the translational expression and phosphorylation of CREB (pCREB) in… CONTINUE READING

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