Differential effects of flavonoid compounds on tumor promoter-induced activation of the human CYP1A2 enhancer.

@article{Shih2000DifferentialEO,
  title={Differential effects of flavonoid compounds on tumor promoter-induced activation of the human CYP1A2 enhancer.},
  author={H Shih and George V Pickwell and Linda C. Quattrochi},
  journal={Archives of biochemistry and biophysics},
  year={2000},
  volume={373 1},
  pages={
          287-94
        }
}
Flavonoids, a family of naturally occurring polyphenolic compounds found in many fruits, nuts, vegetables, and beverages, appear to inhibit tumor promotion as part of their chemopreventive properties. To investigate at the molecular level the ability of flavonoids to inhibit tumor-promoting activity, we developed a cell line designed to screen for flavonoids that block the tumor promoter-mediated induction of activator protein-1 (AP-1) transcriptional activity. This cell line, T2Luc, is a HepG2… CONTINUE READING
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