Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release

@article{Kansra2005DifferentialEO,
  title={Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release},
  author={Sanjay Kansra and Sayaka Yamagata and Leighton Sneade and Lauren A Foster and Nira Ben-Jonathan},
  journal={Molecular and Cellular Endocrinology},
  year={2005},
  volume={239},
  pages={27-36}
}
Anti-estrogens act by inhibiting estrogen receptor (ER) function. Unlike raloxifene and tamoxifen which exhibit both antagonist and agonist properties, ICI 182,780 (ICI) is considered a "pure" anti-estrogen devoid of any agonistic activities. Whereas there is ample information on the effects of anti-estrogens on the breast and uterus, little is known about their action on the pituitary, the estrogen-sensitive master endocrine gland. Our objectives were to: (1) compare the effects of ICI… Expand
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