Differential effects of enrichment on learning and memory function in NR2B transgenic mice

  title={Differential effects of enrichment on learning and memory function in NR2B transgenic mice},
  author={Y. Tang and H. Wang and R. Feng and M. Kyin and J. Tsien},
  • Y. Tang, H. Wang, +2 authors J. Tsien
  • Published 2001
  • Psychology, Medicine
  • Neuropharmacology
  • It has been known that environmental enrichment leads to better learning and memory in mice. However, the molecular mechanisms are not known. In this study, we used the 10th-12th of the NR2B transgenic (Tg) lines, in which the NMDA receptor function is enhanced via the NR2B subunit transgene in neurons of the forebrain, to test the hypothesis of the involvement of NMDA receptor function in enrichment-induced better learning and memory. Consistent with our previous results, both larger long-term… CONTINUE READING
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