Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus

@article{Venderov2005DifferentialEO,
  title={Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus},
  author={Kateřina Venderov{\'a} and Timothy Matthew Brown and Jonathan M. Brotchie},
  journal={Experimental Neurology},
  year={2005},
  volume={194},
  pages={284-287}
}

Cannabinoid Agonists Stimulate [3H]GABA Release in the Globus Pallidus of the Rat When Gi Protein-Receptor Coupling Is Restricted: Role of Dopamine D2 Receptors

CB1 receptor activation has dual effects on GABA release in the globus pallidus through mechanisms that are independent of D2 receptor activation, which is consistent with the proposal that D2 receptors reduce Gi/o proteins available for binding to the CB1 receptor.

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In this chapter, the anatomical, neurochemical, electrophysiological, and pharmacological bases that sustain the importance of the cannabinoid system in basal ganglia function are reviewed, attempting to present current information and future lines for research on the therapeutic potential of this system inBasal ganglia disorders.

Studies on the role of cannabinoids on dopamine transporter function: an optical method

PC results showed that differentiated PC12 cells had low expressions of the cannabinoid receptor 1 gene (CNR1), making this cell line unsuitable for this cannabinoid study, making it possible to assess transporter activity by quantitative fluorescence technique.

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