Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus

@article{Venderov2005DifferentialEO,
  title={Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus},
  author={K. Venderov{\'a} and T. Brown and J. Brotchie},
  journal={Experimental Neurology},
  year={2005},
  volume={194},
  pages={284-287}
}
In the globus pallidus, cannabinoid CB(1) receptors are localized pre-synaptically on GABAergic neurons. We assessed the influence of the endocannabinoids, anandamide, 2-arachidonoyl-glycerol (2-AG) and noladin ether, on the uptake of [(3)H]-GABA in pallidal slices from rat. Both 2-AG and noladin ether increased [(3)H]-GABA uptake (by 40.8 +/- 8.0% and 38.4 +/- 12.5%). The effect of 2-AG was blocked by the cannabinoid CB(1) receptor antagonist AM 251. In contrast, neither anandamide nor the… Expand
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