Differential effects of ebselen on neutrophil recruitment, chemokine, and inflammatory mediator expression in a rat model of lipopolysaccharide-induced pulmonary inflammation.

@article{Haddad2002DifferentialEO,
  title={Differential effects of ebselen on neutrophil recruitment, chemokine, and inflammatory mediator expression in a rat model of lipopolysaccharide-induced pulmonary inflammation.},
  author={E B Haddad and Kerryn McCluskie and Mark A Birrell and Dominika Dabrowski and Michela Pecoraro and Steve Underwood and Bei Chen and George T. De Sanctis and Steve E Webber and Martyn L. Foster and Maria G Belvisi},
  journal={Journal of immunology},
  year={2002},
  volume={169 2},
  pages={974-82}
}
We postulated that the seleno-organic compound ebselen would attenuate neutrophil recruitment and activation after aerosolized challenge with endotoxin (LPS) through its effect as an antioxidant and inhibitor of gene activation. Rats were given ebselen (1-100 mg/kg i.p.) followed by aerosolized LPS exposure (0.3 mg/ml for 30 min). Airway inflammatory indices were measured 4 h postchallenge. Bronchoalveolar lavage (BAL) fluid cellularity and myeloperoxidase activity were used as a measure of… CONTINUE READING
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