Differential effects of early-life nutrient restriction in long-lived GHR-KO and normal mice

@article{Fang2017DifferentialEO,
  title={Differential effects of early-life nutrient restriction in long-lived GHR-KO and normal mice},
  author={Yimin Fang and Samuel McFadden and Justin Darcy and Cristal M. Hill and Joshua A Huber and Steve Verhulst and John J. Kopchick and Richard L. Miller and Liou Y Sun and Andrzej Bartke},
  journal={GeroScience},
  year={2017},
  volume={39},
  pages={347-356}
}
There is increasing evidence that growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling (collectively referred to as somatotropic signaling) during development has a profound influence on aging and longevity. Moreover, the absence of GH action was shown to modify responses of adult mice to calorie restriction (CR) and other antiaging interventions. It was therefore of interest to determine whether GH resistance in GH receptor knockout (GHR-KO) mice would modify the effects of… CONTINUE READING