Differential effects of duration and age on the consequences of neuroinflammation in the hippocampus.

@article{Bardou2013DifferentialEO,
  title={Differential effects of duration and age on the consequences of neuroinflammation in the hippocampus.},
  author={Isabelle Bardou and Holly M. Brothers and Roxanne M. Kaercher and Sarah C Hopp and Gary L. Wenk},
  journal={Neurobiology of aging},
  year={2013},
  volume={34 10},
  pages={2293-301}
}
The current study investigated the hypothesis that the duration of the proinflammatory environment plays a critical role in the brain's response that results in negative consequences on cognition, biochemistry, and pathology. Lipopolysaccharide or artificial cerebrospinal fluid was slowly (250 ηg/h) infused into the fourth ventricle of young (3-month-old), adult (9-month-old), or aged (23-month-old) male F-344 rats for 21 or 56 days. The rats were then tested in the water pool task and… CONTINUE READING