Differential effects of dopaminergic agents on locomotor sensitisation and on the reinstatement of cocaine-seeking and food-seeking behaviour

@article{Dias2004DifferentialEO,
  title={Differential effects of dopaminergic agents on locomotor sensitisation and on the reinstatement of cocaine-seeking and food-seeking behaviour},
  author={Carine Dias and Servane B Lachize and V. Boilet and E. Huitelec and Martine Cador},
  journal={Psychopharmacology},
  year={2004},
  volume={175},
  pages={414-427}
}
The dopaminergic pathways are involved in natural and drug reward related processes. To compare the respective involvement of the dopaminergic receptors D1, D2 and D3 in natural-seeking versus drug-seeking behaviour and evaluate any concomitant expression of locomotor sensitisation. In separate experiments, male Wistar rats were trained to self-administer cocaine (0.25 mg/infusion) or to press a lever to obtain food pellets. Following a prolonged period of extinction, reinstatement of lever… CONTINUE READING

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Highly Influenced

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