• Corpus ID: 40046038

Differential effects of direct and indirect dopamine agonists on the induction of gnawing in C57Bl/6J mice.

  title={Differential effects of direct and indirect dopamine agonists on the induction of gnawing in C57Bl/6J mice.},
  author={Ezio Tirelli and Jeffrey M. Witkin},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={273 1},
  • E. Tirelli, J. Witkin
  • Published 1 April 1995
  • Biology, Chemistry
  • The Journal of pharmacology and experimental therapeutics
The ability of indirect dopamine agonists to induce gnawing in male C57Bl/6J mice was compared to that of direct dopamine agonists acting at dopamine D1 or D2 receptor subtypes. Holes left by the mice on the corrugations of packing cardboard were used as an objective index of gnawing. Indirect dopamine agonists, including dopamine releasers such as fencamfamine, (+)-amphetamine and amfenolic acid and dopamine uptake inhibitors such as cocaine, GBR 12909 (1-[2-[bis(4-fluorophenyl)methoxy]ethyl… 
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