Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta.

@article{Takechi2010DifferentialEO,
  title={Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta.},
  author={Ryusuke Takechi and Stuart Galloway and Menuka Pallebage-Gamarallage and Cheryl L Wellington and Russell D. Johnsen and Satvinder S Dhaliwal and John Charles Mamo},
  journal={The British journal of nutrition},
  year={2010},
  volume={103 5},
  pages={
          652-62
        }
}
Some dietary fats are a risk factor for Alzheimer's disease (AD) but the mechanisms for this association are presently unknown. In the present study we showed in wild-type mice that chronic ingestion of SFA results in blood-brain barrier (BBB) dysfunction and significant delivery into the brain of plasma proteins, including apo B lipoproteins that are endogenously enriched in amyloid-beta (Abeta). Conversely, the plasma concentration of S100B was used as a marker of brain-to-blood leakage and… CONTINUE READING
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