Differential effects of diesel exhaust particles on T cell differentiation and autoimmune disease

@inproceedings{ODriscoll2018DifferentialEO,
  title={Differential effects of diesel exhaust particles on T cell differentiation and autoimmune disease},
  author={Chelsea A. O’Driscoll and Leah A Owens and Madeline E. Gallo and Erica J Hoffmann and Amin Afrazi and Mei Han and John H Fechner and James J. Schauer and Christopher A. Bradfield and Joshua D Mezrich},
  booktitle={Particle and Fibre Toxicology},
  year={2018}
}
BackgroundExposure to particulate matter (PM) has been associated with increased incidence and severity of autoimmune disease. Diesel PM is primarily composed of an elemental carbon core and adsorbed organic compounds such as polycyclic aromatic hydrocarbons (PAHs) and contributes up to 40% of atmospheric PM. The organic fraction (OF) of PM excludes all metals and inorganics and retains most organic compounds, such as PAHs. Both PM and OF increase inflammation in vitro and aggravate autoimmune… CONTINUE READING
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