Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes.

@article{NishimotoMorita2009DifferentialEO,
  title={Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes.},
  author={Kirika Nishimoto-Morita and Hye-Won Shin and Hiroko Mitsuhashi and Masashi Kitamura and Qian Zhang and Ludger Johannes and Kazuhisa Nakayama},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 16},
  pages={10583-92}
}
ARFRP1 and ARL1, which are both ARF-like small GTPases, are mammalian orthologs of yeast Arl3p and Arl1p, respectively. In yeast, Arl3p targeted to trans-Golgi network (TGN) membranes activates Arl1p, and the activated Arl1p in turn recruits a GRIP domain-containing protein; this complex regulates retrograde transport to the TGN and anterograde transport from the TGN. In the present study, using RNA interference-mediated knockdown of ARFRP1 and ARL1, we have examined whether the orthologs of… CONTINUE READING

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