Differential effects of cyclic nucleotide analogues and GnRH on LH synthesis and release.

@article{Liu1981DifferentialEO,
  title={Differential effects of cyclic nucleotide analogues and GnRH on LH synthesis and release.},
  author={T. Liu and G. L. Jackson},
  journal={The American journal of physiology},
  year={1981},
  volume={241 1},
  pages={
          E6-13
        }
}
  • T. Liu, G. L. Jackson
  • Published 1 July 1981
  • Chemistry, Medicine
  • The American journal of physiology
We compared the effects of gonadotropin-releasing hormone (GnRH) and cyclic nucleotides on biosynthesis and release of luteinizing hormone (LH) by rat anterior pituitary glands (APs). APs from ovariectomized rats were incubated in the presence of test compounds, [3H]glucosamine, and [14C]alanine. GnRH significantly (P less than 0.01) increased both incorporation of [3H]glucosamine into LH (glycosylation) and release of immunoreactive LH (IR-LH) and [3H]LH. None of the cyclic nucleotides alone… Expand
20 Citations
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TLDR
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The results demonstrate the independence of LH release from cAMP accumulation in cultured pituicytes, suggesting that cAMP is not required for stimulation of LHrelease from these cells and that GnRH acts on LH secretion by a different mechanism. Expand
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  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
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TLDR
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