Differential effects of cocaine and ketamine on time estimation: Implications for neurobiological models of interval timing

  title={Differential effects of cocaine and ketamine on time estimation: Implications for neurobiological models of interval timing},
  author={Ruey-Kuang Cheng and Christopher J. MacDonald and Warren H. Meck},
  journal={Pharmacology Biochemistry and Behavior},
Effects of Amphetamine and Cocaine on Behavior Maintained by Differential Reinforcement of Low-Rate-Response (DRL) Schedule
The effects of amphetamines and cocaine on DRL behavior as reviewed here further highlight the need for additional research to probe neurobehavioral mechanisms that may underlie DRLbehavior as manifested by both burst responding and timing the emission of the operant response.
Ethanol effects on impulsivity in two mouse strains: similarities to diazepam and ketamine
Ethanol's ability to increase impulsivity in the 5-CSRTT is mediated by both common and different neurotransmitter systems in the two strains of mice and is dependent on the task's parameters.
Acute ethanol potentiates the clock-speed enhancing effects of nicotine on timing and temporal memory.
  • W. Meck
  • Medicine, Biology
    Alcoholism, clinical and experimental research
  • 2007
The observation that ethanol pretreatment potentiates the clock-speed enhancing effects of subsequently administered nicotine is discussed in terms of the role of alpha7-nicotinic acetylcholine receptors and dopamine-glutamate interactions in cortico-striatal circuits thought to subserve interval timing.
Habit formation and the loss of control of an internal clock: inverse relationship between the level of baseline training and the clock-speed enhancing effects of methamphetamine
A transition from DA-sensitive to DA-insensitive mechanisms is proposed to account for the loss of control of clock speed, as timing behaviors associated with the PI procedure gradually become learned habits through the strengthening of DA–glutamate connections.
Time Perception in Cocaine-Dependent Patients
Regardless of the time interval tested, the results showed comparable temporal ability in patients and controls, but higher temporal variability in patients, consistent with impairment of frontally-mediated cognitive functions involved in time perception rather than impairment in time processing per se.


Differential effects of clozapine and haloperidol on interval timing in the supraseconds range
The proposal that typical antipsychotic drugs such as haloperidol and atypical antipsychotics such as clozapine exert differential effects on dopaminergic, serotonergic, and glutamatergic systems within the cortex and striatum, two brain regions shown to be crucial for interval timing, is supported.
Ethanol Enhances Nicotine's Effects on DRL Performance in Rats
Comparison of drug effects on the performance of two timing tasks in rats
Individual Differences in Cocaine-induced Locomotor Activity in Rats: Behavioral Characteristics, Cocaine Pharmacokinetics, and the Dopamine Transporter
The results argue against several likely explanations for individual differences in cocaine-induced behavior and highlight the influence of a single cocaine exposure on subsequent behavioral responses to the drug.
Differential modulation of clock speed by the administration of intermittent versus continuous cocaine.
The results suggest that the mechanisms of sensitization may play a considerable role in drug-induced alterations of the perception of time in rats, and that stimulant-induced increases in clock speed can be sensitized.
The differential effects of haloperidol and methamphetamine on time estimation in the rat
Since methamphetamine releases several catecholamines, including dopamine, and haloperidol blocks dopamine receptors, it is plausible that the horizontal location of the psychometric function (the speed of the clock) is related to the effective level of dopamine.
Acute effects of d-amphetamine on the differential reinforcement of low-rate (DRL) schedule behavior in the rat: comparison with selective dopamine receptor antagonists.
Different behavioral components of the DRL task are differentially sensitive to pharmacological manipulation, suggesting that the effectiveness of d-amphetamine is derived from its drug action as a psychostimulant.