Differential effects of cocaine and ketamine on time estimation: Implications for neurobiological models of interval timing

@article{Cheng2006DifferentialEO,
  title={Differential effects of cocaine and ketamine on time estimation: Implications for neurobiological models of interval timing},
  author={R. Cheng and C. MacDonald and W. Meck},
  journal={Pharmacology Biochemistry and Behavior},
  year={2006},
  volume={85},
  pages={114-122}
}
The present experiment examined the effects of cocaine (0.0 and 15 mg/kg, i.p.) and ketamine (0.0, 10.0 and 15 mg/kg, i.p.) on timing behavior using a 12-s differential reinforcement of low rates (DRL) procedure and a 2- vs. 8-s bisection procedure in rats. DRL (time production) and bisection (time perception) procedures are sensitive to effects of dopaminergic drugs and provide an assessment of the accuracy and precision of interval timing as well as the subject's level of impulsivity. When… Expand
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