Differential effects of coadministration of fluoxetine and WAY-100635 on serotonergic neurotransmission in vivo: sensitivity to sequence of injections.

@article{Taber2000DifferentialEO,
  title={Differential effects of coadministration of fluoxetine and WAY-100635 on serotonergic neurotransmission in vivo: sensitivity to sequence of injections.},
  author={Matthew T. Taber and Gene G. Kinney and Rick L Pieschl and Frank D. Yocca and Valentin K. Gribkoff},
  journal={Synapse},
  year={2000},
  volume={38 1},
  pages={17-26}
}
Serotonin 5-HT(1A) receptor antagonists potentiate the effects of serotonin reuptake inhibitors on extracellular serotonin levels in a variety of brain regions. These effects are quite variable, however, with reports indicating potentiations of anywhere from 100-1900%. One factor that might impact the magnitude of such potentiations is the timing of administration of the two agents; reports in which the reuptake inhibitor is given prior to the serotonin receptor antagonist consistently report… CONTINUE READING